Role of phosphatidylinositol 4,5-bisphosphate in Ras/Rac-induced disruption of the cortactin-actomyosin II complex and malignant transformation.

@article{He1998RoleOP,
  title={Role of phosphatidylinositol 4,5-bisphosphate in Ras/Rac-induced disruption of the cortactin-actomyosin II complex and malignant transformation.},
  author={Hong He and Toshiki Watanabe and Xi Zhan and Chen-Che Huang and Ed Schuuring and Kiyoko Fukami and Tadaomi Takenawa and C. Promod Chandra Kumar and Richard J. Simpson and Hiroshi Maruta},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 7},
  pages={3829-37}
}
Oncogenic Ras mutants such as v-Ha-Ras cause a rapid rearrangement of actin cytoskeleton during malignant transformation of fibroblasts or epithelial cells. Both PI-3 kinase and Rac are required for Ras-induced malignant transformation and membrane ruffling. However, the signal transduction pathway(s) downstream of Rac that leads to membrane ruffling and other cytoskeletal change(s) as well as the exact biochemical nature of the cytoskeletal change remain unknown. Cortactin/EMS1 is the first… CONTINUE READING

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