Role of phosphatidylinositol 3-kinase/AKT as a survival pathway against CYP2E1-dependent toxicity.

@article{Caro2006RoleOP,
  title={Role of phosphatidylinositol 3-kinase/AKT as a survival pathway against CYP2E1-dependent toxicity.},
  author={Andr{\'e}s Caro and Arthur I. Cederbaum},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2006},
  volume={318 1},
  pages={360-72}
}
The objective of this work was to evaluate the possible role of PI3-kinase/AKT as a survival pathway against CYP2E1-dependent toxicity. E47 cells (HepG2 cells transfected with human CYP2E1 cDNA) exposed to 25 microM iron-nitrilotriacetate+5 microM arachidonic acid (AA+Fe) developed higher toxicity than C34 cells (HepG2 cells transfected with empty plasmid). Toxicity was associated with increased oxidative stress and activation of calcium-dependent hydrolases calpain and phospholipase A2… CONTINUE READING
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