Role of phosphatases in lymphocyte activation.

  title={Role of phosphatases in lymphocyte activation.},
  author={Benjamin G Neel},
  journal={Current opinion in immunology},
  volume={9 3},
Many lymphocyte signaling pathways are regulated by protein tyrosyl phosphorylation, which is controlled by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Substantial progress has been made in defining the functions of lymphocyte PTPs. Individual PTPs can enhance or diminish cell signaling levels. The transmembrane PTP CD45 is a key positive element in multiple lymphocyte signaling pathways in vivo. New insights into the function of individual CD45 isoforms have… CONTINUE READING
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