Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts.

@article{Swamy2004RoleOP,
  title={Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts.},
  author={S. Swamy and P. Tan and Y. Zhu and J. Lu and H. N. Achuth and S. Moochhala},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={314 3},
  pages={
          661-6
        }
}
Wound healing is a complex process involving a number of related genes and receptors. Using cDNA microarrays, we explored the global gene expression profile of phenytoin (20microg/ml) induced changes to human dermal fibroblasts. Microarray data analysis revealed approximately 1500 genes were differentially expressed by 2.5-fold. At 3, 6, 12, and 24h, the transcripts of the major growth factors involved in wound healing and their receptors were increased. This was further confirmed by RT-PCR… Expand
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References

SHOWING 1-10 OF 25 REFERENCES
Up-regulation of keratinocyte growth factor and receptor: a possible mechanism of action of phenytoin in wound healing.
  • S. Das, I. Olsen
  • Biology, Medicine
  • Biochemical and biophysical research communications
  • 2001
  • 19
Large induction of keratinocyte growth factor expression in the dermis during wound healing.
  • 570
  • PDF
Human keratinocyte growth factor effects in a porcine model of epidermal wound healing
  • 205
  • PDF
The transcriptional program in the response of human fibroblasts to serum.
  • 2,050
  • PDF
Stimulation of all epithelial elements during skin regeneration by keratinocyte growth factor
  • 193
  • PDF
The effects of phenytoin (5,5-diphenylhydantoin) on human gingival fibroblasts in culture.
  • 35
...
1
2
3
...