Role of persistent, non-genotoxic tissue damage in rodent cancer and relevance to humans.

@article{Grasso1991RoleOP,
  title={Role of persistent, non-genotoxic tissue damage in rodent cancer and relevance to humans.},
  author={Piergiorgio Grasso and Michael Sharratt and Andrea J. Cohen},
  journal={Annual review of pharmacology and toxicology},
  year={1991},
  volume={31},
  pages={
          253-87
        }
}
This review has focused on the importance of cellular proliferation in neoplasia induced by nongenotoxic carcinogens and has not attempted to address the mechanisms involved in the progression from the hyperplastic to the neoplastic state. Major advances in this area are likely in the next decade and should explain how cells in an abnormally high proliferative state are rendered more vulnerable either to the action of endogenous or environmental mutagens or to defects in cell reproduction, thus… CONTINUE READING
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