Role of peroxisome proliferator-activated receptor-gamma in hematologic malignancies.

@article{Konopleva2002RoleOP,
  title={Role of peroxisome proliferator-activated receptor-gamma in hematologic malignancies.},
  author={Marina Y Konopleva and Michael Andreeff},
  journal={Current opinion in hematology},
  year={2002},
  volume={9 4},
  pages={
          294-302
        }
}
Members of the nuclear receptor superfamily, including retinoic acid receptors (RARs), retinoid X receptors (RXRs), and vitamin D receptors (VDRs), are transcription factors that control many important cellular functions, and their ligands are widely used in several clinical indications. The latest family member is the peroxisome proliferator-activated receptor-gamma (PPARgamma), which is highly expressed in normal monocytes, different leukemias, and epithelial malignancies. PPARgamma ligands… CONTINUE READING

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