Role of peroxiredoxin 1 and peroxiredoxin 4 in protection of respiratory syncytial virus-induced cysteinyl oxidation of nuclear cytoskeletal proteins.

@article{Jamaluddin2010RoleOP,
  title={Role of peroxiredoxin 1 and peroxiredoxin 4 in protection of respiratory syncytial virus-induced cysteinyl oxidation of nuclear cytoskeletal proteins.},
  author={Mohammad Jamaluddin and John E Wiktorowicz and Kizhake V Soman and Istvan Boldogh and Jeffrey D Forbus and Heidi Spratt and Roberto P Garofalo and Allan R. Brasier},
  journal={Journal of virology},
  year={2010},
  volume={84 18},
  pages={
          9533-45
        }
}
The respiratory epithelium plays a central role in innate immunity by secreting networks of inflammatory mediators in response to respiratory syncytial virus (RSV) infection. Previous proteomic studies focusing on the host cellular response to RSV indicated the existence of a nuclear heat shock response and cytoplasmic depletion of antioxidant proteins in model type II-like airway epithelial cells. Here, we increased the depth of nuclear proteomic interrogation by using fluorescence difference… CONTINUE READING

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