Role of peripheral versus spinal 5-HT(7) receptors in the modulation of pain undersensitizing conditions.

@article{Brenchat2012RoleOP,
  title={Role of peripheral versus spinal 5-HT(7) receptors in the modulation of pain undersensitizing conditions.},
  author={Alex Brenchat and Daniel Zamanillo and Michel Hamon and L{\'a}zaro Enrique Yliz{\'a}stigui Romero and Jos{\'e} Miguel Vela},
  journal={European journal of pain},
  year={2012},
  volume={16 1},
  pages={
          72-81
        }
}
Several studies have suggested that 5-HT(7) receptors are involved in nociceptive processing but the exact contribution of peripheral versus central 5-HT(7) receptors still needs to be elucidated. In the present study, the respective roles of peripheral and spinal 5-HT(7) receptors in the modulation of mechanical hypersensitivity were investigated under two different experimental pain conditions. In a first set of experiments, the selective 5-HT(7) receptor agonist, E-57431, was systemically… CONTINUE READING

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