Role of papillomavirus E1 initiator dimerization in DNA replication.

  title={Role of papillomavirus E1 initiator dimerization in DNA replication.},
  author={Stephen Schuck and Arne Stenlund},
  journal={Journal of virology},
  volume={79 13},
Viral initiator proteins are polypeptides that form oligomeric complexes on the origin of DNA replication (ori). These complexes carry out a multitude of functions related to initiation of DNA replication, and although many of these functions have been characterized biochemically, little is understood about how the complexes are assembled. Here we demonstrate that loss of one particular interaction, the dimerization between E1 DNA binding domains, has a severe effect on DNA replication in vivo… CONTINUE READING

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