Role of pagL and lpxO in Bordetella bronchiseptica lipid A biosynthesis.

  title={Role of pagL and lpxO in Bordetella bronchiseptica lipid A biosynthesis.},
  author={Iain MacArthur and Jace W. Jones and David R. Goodlett and Robert K Ernst and Andrew Preston},
  journal={Journal of bacteriology},
  volume={193 18},
PagL and LpxO are enzymes that modify lipid A. PagL is a 3-O deacylase that removes the primary acyl chain from the 3 position, and LpxO is an oxygenase that 2-hydroxylates specific acyl chains in the lipid A. pagL and lpxO homologues have been identified in the genome of Bordetella bronchiseptica, but in the current structure for B. bronchiseptica lipid A the 3 position is acylated and 2-OH acylation is not reported. We have investigated the role of B. bronchiseptica pagL and lpxO in lipid A… CONTINUE READING
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