Role of pH in protection by low sodium against hypoxic injury in isolated perfused rat livers.

@article{Vairetti2006RoleOP,
  title={Role of pH in protection by low sodium against hypoxic injury in isolated perfused rat livers.},
  author={Mariapia Vairetti and Plinio Richelmi and Francantonio Bert{\`e} and Robert T. Currin and John J. Lemasters and Roberto Imberti},
  journal={Journal of hepatology},
  year={2006},
  volume={44 5},
  pages={
          894-901
        }
}
BACKGROUND/AIMS The purpose of the present study was to characterize the role of Na+, pH and cellular swelling in the pathogenesis of hypoxic injury to rat livers. METHODS AND RESULTS When livers were perfused with hypoxic Krebs-Henseleit bicarbonate buffer (KHB) containing 143 mM Na+, release of LDH began after 30 min and was maximal after 60 min. In livers perfused with choline-substituted low-Na+ KHB (25 mM Na+), LDH release began after 60 min and peaked after 120 min or longer… CONTINUE READING

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