Role of p53 gene mutation in tumor aggressiveness of intracranial meningiomas.

@article{Cho1999RoleOP,
  title={Role of p53 gene mutation in tumor aggressiveness of intracranial meningiomas.},
  author={Hyun-yee Cho and Seung Yeon Ha and Se Hoon Park and Keunchil Park and Yang Seok Chae},
  journal={Journal of Korean Medical Science},
  year={1999},
  volume={14},
  pages={199 - 205}
}
The mutations that occur in the p53 tumor suppressor gene have been studied in various human malignant tumors. However, little is known about this gene in meningiomas. To investigate the relationship and frequency of p53 gene mutations, the p53 polymerase chain reaction-single stranded conformational polymorphism (PCR-SSCP) and immunohistochemical study were performed on the 41 intracranial meningiomas (21 benign, 11 atypical, and 9 malignant). The higher the p53 protein expression rate, the… CONTINUE READING
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