Role of p53 family members in apoptosis.

@article{Sheikh2000RoleOP,
  title={Role of p53 family members in apoptosis.},
  author={Muhammed S Sheikh and Albert J. Fornace},
  journal={Journal of cellular physiology},
  year={2000},
  volume={182 2},
  pages={171-81}
}
p53-mediated apoptosis involves multiple mechanisms. A number of p53-regulated apoptosis-related genes have been identified. Some of these genes encode proteins that are important in controlling the integrity of mitochondria while the others code for membrane death receptors. p53 may also induce apoptosis by interfering with the growth factor-mediated survival signals. Although the transactivation-deficient p53 can induce apoptosis, evidence suggests that both the transcription-dependent and… CONTINUE READING

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