Role of p53-dependent placental apoptosis in the reproductive and developmental toxicities of caffeine in rodents.

@article{Huang2012RoleOP,
  title={Role of p53-dependent placental apoptosis in the reproductive and developmental toxicities of caffeine in rodents.},
  author={Jing Huang and Shu Qin Zhou and Jie Ping and Xiaoliang Pan and Gai Liang and Dan Xu and H. M. Kou and Chong Bao and Hui Wang},
  journal={Clinical and experimental pharmacology & physiology},
  year={2012},
  volume={39 4},
  pages={357-63}
}
The aim of the present study was to evaluate the role of placental apoptosis in mediating the reproductive and developmental toxicity of caffeine in rodents. Female Kunming mice were treated with caffeine (60, 120 and 240 mg/kg per day) before and during pregnancy. The conception rate, maternal bodyweight gain, placental weight and indices of fetal developmental, including the rate of intrauterine growth retardation (IUGR; i.e. the actual number of fetuses exhibiting IUGR as a percentage of the… CONTINUE READING