Role of p53 and p73 genes polymorphisms in susceptibility to esophageal cancer: a case control study in a northern Indian population

@article{Umar2011RoleOP,
  title={Role of p53 and p73 genes polymorphisms in susceptibility to esophageal cancer: a case control study in a northern Indian population},
  author={Meenakshi Umar and Rohit Upadhyay and Rohini Khurana and Shaleen Kumar and Uday C Ghoshal and Balraj Mittal},
  journal={Molecular Biology Reports},
  year={2011},
  volume={39},
  pages={1153-1162}
}
Genetic variants in p53 and in its homologue p73 may modulate Esophageal Cancer (EC) risk because they are supposed to influence cell cycle progression, apoptosis and DNA repair. Therefore, we aimed to evaluate the association of p53 intron3 16 bp duplication and p73 G4C14-to-A4T14 polymorphisms with susceptibility to EC in a northern Indian population in 255 EC patients and 255 age and sex matched healthy controls. We found that p53 intron3 16 bp duplication polymorphism was not associated… CONTINUE READING

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References

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Showing 1-10 of 55 references

Expression of p73, ER and PR in esophageal carcinoma and precancerous lesions

  • S Fan, J Aie, +5 authors J Wei
  • Chn German J Clin Oncol
  • 2006
Highly Influential
11 Excerpts

A case Fig. 1 Diagram showing different pathways regulated by p73 in response to DNA damage and Hypothesis of study

  • P Galli, G Cadoni, +7 authors S Boccia
  • Mol Biol Rep
  • 2009
Highly Influential
3 Excerpts

A case-control study on the effect of p53 and p73 gene polymorphisms on gastric cancer risk and progression

  • E De Feo, R Persiani, +8 authors S Boccia
  • Mutat Res
  • 2009
1 Excerpt

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