Role of p53 and CDKN2A Inactivation in Human Squamous Cell Carcinomas

@article{Pacifico2007RoleOP,
  title={Role of p53 and CDKN2A Inactivation in Human Squamous Cell Carcinomas},
  author={Alessia Pacifico and Giovanni Leone},
  journal={Journal of Biomedicine and Biotechnology},
  year={2007},
  volume={2007},
  pages={1 - 6}
}
p53 tumor suppressor gene is the most commonly mutated gene in human and mouse cancers. Disruption of the p53 and Rb pathways is a fundamental trend of most human cancer cells. Inactivation of CDKN2A can lead to deregulation of these two pathways. Genetic abnormalities in CDKN2A gene have been well documented in human melanoma but their involvement in human nonmelanoma skin cancer (NMSC) and in particular in squamous cell carcinoma (SCC) is less clear. Several studies have shown that human SCCs… CONTINUE READING