Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage.

Abstract

p38 mitogen-activated protein kinase (MAPK) activates a number of heat shock proteins (HSPs), including HSP27 and alpha(B)-crystallin, in response to stress. Activation of HSP27 or alpha(B)-crystallin is known to protect organs/cells by increasing the stability of actin microfilaments. Although our previous studies showed that 17beta-estradiol (E(2… (More)

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@article{Hsu2007RoleOP, title={Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage.}, author={Jun-Te Hsu and Ya-Ching Hsieh and Wen Hong Kan and Jian Jhen Chen and Mashkoor A. Choudhry and Martin G. Schwacha and Kirby I. Bland and Irshad H. Chaudry}, journal={American journal of physiology. Heart and circulatory physiology}, year={2007}, volume={292 6}, pages={H2982-7} }