Role of p27Kip1 as a transcriptional regulator

@inproceedings{Bachs2018RoleOP,
  title={Role of p27Kip1 as a transcriptional regulator},
  author={Oriol Bachs and Edurne Gallastegui and Serena Orlando and Anna Bigas and Jos{\'e} Manuel Morante-Redolat and J. M. Serratosa and Isabel Fari{\~n}as and Rosa Aligu{\'e} and Mar{\'i}a Jes{\'u}s Pujol},
  booktitle={Oncotarget},
  year={2018}
}
The protein p27Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase (Cdk) inhibitors. It interacts with both the catalytic and the regulatory subunit (cyclin) and introduces a region into the catalytic cleave of the Cdk inducing its inactivation. Its inhibitory capacity can be modulated by specific tyrosine phosphorylations. p27Kip1 also behaves as a transcriptional regulator. It associates with specific chromatin domains through different transcription factors. ChIP on chip, ChIP… CONTINUE READING
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