Role of p21 RAS in p210 bcr-abl transformation of murine myeloid cells.

@article{Mandanas1993RoleOP,
  title={Role of p21 RAS in p210 bcr-abl transformation of murine myeloid cells.},
  author={R. A. Mandanas and D. Leibowitz and K. Gharehbaghi and T. Tauchi and G. Burgess and K. Miyazawa and H. Jayaram and H. S. Boswell},
  journal={Blood},
  year={1993},
  volume={82 6},
  pages={
          1838-47
        }
}
The p21 RAS product has been implicated as part of the downstream signaling of certain nonreceptor tyrosine kinase oncogenes and several growth factor receptor-ligand interactions. We have reported that the chronic myelogenous leukemia oncogene p210 bcr-abl transforms a growth-factor-dependent myeloid cell line NFS/N1.H7 to interleukin-3 (IL-3) independence. In these p210 bcr-abl-transformed cells (H7 bcr-abl.A54) and in two other murine myeloid cell lines transformed to IL-3 independence by… Expand
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