Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells.

  title={Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells.},
  author={Wai Kei Kwok and Ming-tat Ling and Hiu Fung Yuen and Y C Wong and Xianghong Wang},
  volume={28 12},
Recently, TWIST, a basic helix-loop-helix transcription factor, is suggested to be an oncogene because of its over-expression in many types of human cancer and its positive role in promoting cell survival. The aim of this study was to investigate the role of TWIST on the growth of human epithelial cells. Using two immortalized human prostate epithelial cell lines, we demonstrated that inactivation of TWIST by small RNA technology led to the promotion of cellular senescence and growth arrest… CONTINUE READING


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