Role of oxyradicals in mutagenicity and DNA damage induced by crocidolite asbestos in mammalian cells.

Abstract

Crocidolite, one of the most carcinogenic forms of asbestos, is mutagenic in cultured mammalian cells when assayed using a system that can detect multilocus deletions. In the present study, we examined the effect of buthionine sulfoximine (BSO) on mutation frequency and the formation of 8-hydroxydeoxyguanosine (8-OHdG) in human-hamster hybrid (A(L)) cells… (More)

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@article{Xu1999RoleOO, title={Role of oxyradicals in mutagenicity and DNA damage induced by crocidolite asbestos in mammalian cells.}, author={Author Xu and Lian Wu and Regina M. Santella and Tom K. Hei}, journal={Cancer research}, year={1999}, volume={59 23}, pages={5922-6} }