Role of oxygen radicals in DNA damage and cancer incidence

  title={Role of oxygen radicals in DNA damage and cancer incidence},
  author={M. Valko and M. Izakovi{\vc} and Milan Mazur and C. Rhodes and J. Telser},
  journal={Molecular and Cellular Biochemistry},
  • M. Valko, M. Izakovič, +2 authors J. Telser
  • Published 2004
  • Chemistry, Medicine
  • Molecular and Cellular Biochemistry
  • The development of cancer in humans and animals is a multistep process. The complex series of cellular and molecular changes participating in cancer development are mediated by a diversity of endogenous and exogenous stimuli. One type of endogenous damage is that arising from intermediates of oxygen (dioxygen) reduction—oxygen-free radicals (OFR), which attacks not only the bases but also the deoxyribosyl backbone of DNA. Thanks to improvements in analytical techniques, a major achievement in… CONTINUE READING
    1,506 Citations
    Oxidative damage and counteracting mechanisms in breast carcinoma
    • 10
    • PDF
    Oxidatively Damaged DNA: A Possible Antigenic Stimulus for Cancer Autoantibodies
    • 5
    Free radicals, metals and antioxidants in oxidative stress-induced cancer.
    • 5,071
    • PDF
    Role of antioxidants in cancer therapy.
    • 163
    Oxidative stress in breast and gynaecological carcinogenesis
    • 10
    • Highly Influenced
    • PDF
    Oxidative and antioxidative mechanisms in oral cancer and precancer: a review.
    • 101
    • Highly Influenced


    Oxyradicals and DNA damage.
    • 1,678
    Role of oxygen free radicals in cancer development.
    • 797
    Oxidative mechanisms in carcinogenesis.
    • 471
    Influence of oxygen radical injury on DNA methylation.
    • 191
    Free radical-induced damage to DNA: mechanisms and measurement.
    • 815
    DNA repair, oxidative stress and aging
    • 12
    Repair of products of oxidative DNA base damage in human cells.
    • 264
    • PDF
    The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis.
    • 453
    Inflammation and oxidative stress in carcinogenesis.
    • 200