Role of oxygen radicals in DNA damage and cancer incidence

@article{Valko2004RoleOO,
  title={Role of oxygen radicals in DNA damage and cancer incidence},
  author={Mari{\'a}n Valko and M{\'a}rio Izakovi{\vc} and Milan Maz{\'u}r and Christopher J. Rhodes and Joshua Telser},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={266},
  pages={37-56}
}
The development of cancer in humans and animals is a multistep process. The complex series of cellular and molecular changes participating in cancer development are mediated by a diversity of endogenous and exogenous stimuli. One type of endogenous damage is that arising from intermediates of oxygen (dioxygen) reduction—oxygen-free radicals (OFR), which attacks not only the bases but also the deoxyribosyl backbone of DNA. Thanks to improvements in analytical techniques, a major achievement in… Expand
Human cytochrome P450 reductase can act as a source of endogenous oxidative DNA damage and genetic instability.
TLDR
It is reported that expression of human NADPH-cytochrome P450 reductase in cultured V79 Chinese hamster cells gives rise to elevated basal levels of oxidative purine modifications after depletion of glutathione, and hOR-expressing cells are identified as a potential source of endogenous oxidative DNA damage and subsequent genetic instability in mammalian cells. Expand
Oxidative damage and counteracting mechanisms in breast carcinoma
Breast cancer is the leading cause of death from cancer among Finnish women, but the ultimate causation of carcinogenesis still remains unclear. Reactive oxygen species (ROS) is a collective term forExpand
REACTIVE OXYGEN SPECIES AND THEIR RELATION TO CARCINOGENESIS
Oxygen reactive free radicals, more known as reactive oxygen species (ROS) have dual nature. On the one hand, they necessary for normal function of the cell, but on the other side when ROS is inExpand
Oxidatively Damaged DNA: A Possible Antigenic Stimulus for Cancer Autoantibodies
TLDR
The results show that ROS induced oxidative damage to DNA in cancer patients generate neo-epitopes that are alien for the immune system, resulting in autoantibody formation. Expand
Damage of DNA and proteins by major lipid peroxidation products in genome stability
TLDR
This review summarizes consequences of LPO products’ presence in cell, particularly 4-hydroxy-2-nonenal, in terms of genomic stability. Expand
Role of antioxidants in cancer therapy.
TLDR
Significant reductions in toxicity may alleviate dose-limiting toxicities so that more patients are able to complete prescribed chemotherapy regimens and thus, in turn, improve the potential for success in terms of tumor response and survival. Expand
Free radicals, metals and antioxidants in oxidative stress-induced cancer.
TLDR
This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors. Expand
Oxidative stress in breast and gynaecological carcinogenesis
TLDR
Results indicate that in breast cancer and endometriosis-associated ovarian cancer, a high level of ROS-derived DNA damage could be significant factor in the initiation stage of carcinogenesis, whereas in later stages carcinomas benefit from lower ROS levels that support tumour growth and survival via cellular signalling. Expand
Oxidative and antioxidative mechanisms in oral cancer and precancer: a review.
TLDR
This review is an attempt to understand the interesting correlation between ROS and RNS mediated cell damage and enzymatic and non-enzymatic defence mechanisms involved in oral cancer development and its progression and the use of antioxidants in Oral cancer prevention and treatment. Expand
8-Hydroxydeoxyguanosine: A valuable predictor of oxidative DNA damage in cancer and diabetes mellitus
TLDR
During oxidative stress in mammalian cells, one of the most potentially oxidized mutagenic DNA lesions formed upon DNA repair is 8-OHdG, a frequently detected nucleoside repair product, suggesting 8- OHdG as a novel and pivotal biomarker in the assessment of various conditions related to generalized, cellular oxidative stress, and oxidative DNA damage. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 219 REFERENCES
Oxyradicals and DNA damage.
TLDR
The levels of oxidative DNA damage reported in many human tissues or in animal models of carcinogenesis exceed the levels of lesions induced by exposure to exogenous carcinogenic compounds, and it seems likely that oxidativeDNA damage is important in the etiology of many human cancers. Expand
Role of oxygen free radicals in cancer development.
TLDR
Reducing the avoidable endogenous and exogenous causes of oxidative stress is, for the present, the safest option and new insights in the action of tumour suppressor genes and the DNA repair mechanisms may lead the way to additional tools against carcinogenesis from OFR. Expand
Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions.
TLDR
The known properties of individual oxidative lesions in terms of their structure, mutagenicity and repairability are summarized. Expand
Oxidative mechanisms in carcinogenesis.
TLDR
This review explores the molecular mechanisms through which free radicals can participate in the carcinogenic process and suggests that free radicals may contribute widely to cancer development in humans. Expand
Influence of oxygen radical injury on DNA methylation.
TLDR
Replacement of guanine with the oxygen radical adduct 8-hydroxyguanine profoundly alters methylation of adjacent cytosines, suggesting a role for oxidative injury in the formation of aberrant DNA methylation patterns during carcinogenesis. Expand
Free radical-induced damage to DNA: mechanisms and measurement.
TLDR
Mechanistic aspects of oxidative damage to DNA and recent developments in the measurement of this type of damage using chromatographic and mass spectrometric techniques are reviewed. Expand
DNA repair, oxidative stress and aging
TLDR
If DNA damage is a key element in senescence, then a major goal in aging research should be to clarify the mechanism involved and the change in DNA repair processes and their efficiency with increasing age. Expand
Repair of products of oxidative DNA base damage in human cells.
TLDR
This work investigated the cellular repair of DNA base damage products in DNA of cultured human lymphoblast cells, which were exposed to oxidative stress by H2O2, and identified 11 modified bases that are known to possess various premutagenic properties. Expand
The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis.
TLDR
Results point to 8-OH-G as an endogenous source of mutations in eukaryotes and to its likely involvement in the process of carcinogenesis and to a possible role in the prevention of cancer. Expand
Reactions of oxyl radicals with DNA.
TLDR
This review focuses on the damage caused to DNA by reactive oxygen-centred radicals, which arise either from the radiolysis of water by ionizing radiation, or from a purely chemical source. Expand
...
1
2
3
4
5
...