Role of oxygen radicals in DNA damage and cancer incidence

@article{Valko2004RoleOO,
  title={Role of oxygen radicals in DNA damage and cancer incidence},
  author={Mari{\'a}n Valko and M{\'a}rio Izakovi{\vc} and Milan Maz{\'u}r and Christopher J Rhodes and Joshua Telser},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={266},
  pages={37-56}
}
The development of cancer in humans and animals is a multistep process. The complex series of cellular and molecular changes participating in cancer development are mediated by a diversity of endogenous and exogenous stimuli. One type of endogenous damage is that arising from intermediates of oxygen (dioxygen) reduction—oxygen-free radicals (OFR), which attacks not only the bases but also the deoxyribosyl backbone of DNA. Thanks to improvements in analytical techniques, a major achievement in… CONTINUE READING
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