Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury.

@article{Naito1998RoleOO,
  title={Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury.},
  author={Yuji Naito and Toshikazu Yoshikawa and Norimasa Yoshida and Motoharu Kondo},
  journal={Digestive diseases and sciences},
  year={1998},
  volume={43 9 Suppl},
  pages={30S-34S}
}
Nonsteroidal antiinflammatory drugs such as aspirin and indomethacin are known to induce gastric mucosal damage including bleeding, ulceration, and perforation in humans and animals. Although it has been proposed that a deficiency of endogenous prostaglandins due to inhibition of cyclooxygenase by the drug is involved in these effects, the exact pathogenic mechanism remains to be elucidated. It has recently been proposed that neutrophil- and oxygen radical-dependent microvascular injuries may… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 63 extracted citations

Urotensin receptors as a new target for CLP induced septic lung injury in mice

Naunyn-Schmiedeberg's Archives of Pharmacology • 2018
View 1 Excerpt

Similar Papers

Loading similar papers…