Role of oxidative stress in the pathogenesis of septic ileus in mice.

@article{Winter2005RoleOO,
  title={Role of oxidative stress in the pathogenesis of septic ileus in mice.},
  author={Benedicte Y De Winter and Luc Van Nassauw and Joris G. De Man and Frederik De Jonge and Albert Jan Bredenoord and Tom C. J. Seerden and Arnold G. Herman and Jean-Pierre Timmermans and Paul A. Pelckmans},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={2005},
  volume={17 2},
  pages={251-61}
}
We investigated the role of oxidative stress in the pathogenesis of septic ileus. Sepsis was induced by intraperitoneal (i.p.) injection of lipopolysaccharides (LPS, 20 mg kg(-1)) in mice. The effect of two i.p. injections of superoxide dismutase [polyethylene glycol (PEG)-SOD, 4000 U kg(-1)] and catalase (PEG-CAT, 15,000 U kg(-1)) was investigated on gastric emptying, intestinal transit and total nitrite plasma concentrations. We also performed immunohistochemical experiments on gastric and… CONTINUE READING

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