Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis.

  title={Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis.},
  author={Anabela Pinto Rolo and Jo{\~a}o Soeiro Teodoro and Carlos Manuel Marques Palmeira},
  journal={Free radical biology & medicine},
  volume={52 1},
The worldwide rising prevalence of obesity and insulin resistance is associated with a parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by excess accumulation of triglyceride in the hepatocyte due to increased inflow of free fatty acids and/or de novo lipogenesis caused by various drugs and multiple defects in energy metabolism. Accumulation of lipids in the hepatocyte impairs the oxidative capacity of the mitochondria, increasing the reduced state of the… CONTINUE READING
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