Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms.

@article{McCormick2007RoleOO,
  title={Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms.},
  author={Michael L. McCormick and Dan Gavrila and Neal L. Weintraub},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 3},
  pages={461-9}
}
The role of inflammation in the pathogenesis of abdominal aortic aneurysms (AAA) is well established. The inflammatory process leads to protease-mediated degradation of the extracellular matrix and apoptosis of smooth muscle cells (SMC), which are the predominant matrix synthesizing cells of the vascular wall. These processes act in concert to progressively… CONTINUE READING