Role of oxidative stress in the apoptotic cell death of cultured cerebellar granule neurons.

@article{Valencia2001RoleOO,
  title={Role of oxidative stress in the apoptotic cell death of cultured cerebellar granule neurons.},
  author={Antonio Guijarro Valencia and Julio Mor{\'a}n},
  journal={Journal of neuroscience research},
  year={2001},
  volume={64 3},
  pages={284-97}
}
When cultured cerebellar granule neurons (CGN) are transferred from 25 mM KCl (K25) to 5 mM KCl (K5) caspase-3 and caspase-8, but not caspase-1 or caspase-9,activities are induced and cells die apoptotically. CGN death was triggered by a [Ca(2+)](i) modification when [Ca(2+)](i) was reduced from 300 nM to 50 nM in a K5 medium. The [Ca(2+)](i) changes were followed by an increase in ROS levels. The generation of both cytosolic and mitochondrial reactive oxygen species (ROS) occurred at three… CONTINUE READING

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