Role of oxidative stress in retinal photoreceptor cell death in N-methyl-N-nitrosourea-treated mice.

@article{Tsuruma2012RoleOO,
  title={Role of oxidative stress in retinal photoreceptor cell death in N-methyl-N-nitrosourea-treated mice.},
  author={Kazuhiro Tsuruma and Mika Yamauchi and Yuta Inokuchi and Sou Sugitani and Masamitsu Shimazawa and Hideaki Hara},
  journal={Journal of pharmacological sciences},
  year={2012},
  volume={118 3},
  pages={
          351-62
        }
}
This study aimed to investigate whether oxidative stress contributes to retinal cell death in a mouse model of photoreceptor degeneration induced by N-methyl-N-nitrosourea (MNU). We measured in vitro MNU-induced radical production in retinal cell cultures of murine 661W photoreceptor-derived cells; RGC-5, a mouse ganglion cell line; and primary retinal cells. The addition of MNU induced oxidative radical generation in 661W and primary retinal cells, but not in RGC-5 cells. Edaravone, a free… CONTINUE READING

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