Role of oxidative stress in pulmonary fibrosis.

  title={Role of oxidative stress in pulmonary fibrosis.},
  author={Claudio Mastruzzo and Nunzio Crimi and Carlo Vancheri},
  journal={Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace},
  volume={57 3-4},
Pulmonary fibrosis can be observed as an end state in a number of chronic inflammatory pulmonary diseases. Although the mechanisms by which lung fibrosis develops are not fully ascertained, recent findings suggest that oxidative stress may play an important role in the pathogenesis of tissue fibrosis affecting apoptosis of both structural and inflammatory cells and altering the cytokine microenvironment balance. Damage and alteration of alveolar epithelial cells is one of the hallmarks of… CONTINUE READING
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