Role of oxidative stress in multiparity-induced endothelial dysfunction.

Abstract

Multiparity is associated with increased risk of cardiovascular disease. We tested whether multiparity induces oxidative stress in rat vascular tissue. Coronary arteries and thoracic aorta were isolated from multiparous and age-matched virgin rats. Relaxation to ACh and sodium nitroprusside (SNP) was measured by wire myography. We also tested the effect of… (More)
DOI: 10.1152/ajpheart.87.2008

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