Role of oxidative stress in catecholamine-induced changes in cardiac sarcolemmal Ca2+ transport.

@article{Tappia2001RoleOO,
  title={Role of oxidative stress in catecholamine-induced changes in cardiac sarcolemmal Ca2+ transport.},
  author={Paramjit S. Tappia and Tomoji Hata and L Hozaima and Milapjit S. Sandhu and Vincenzo Panagia and Naranjan S. Dhalla},
  journal={Archives of biochemistry and biophysics},
  year={2001},
  volume={387 1},
  pages={85-92}
}
Although an excessive amount of circulating catecholamines is known to induce cardiomyopathy, the mechanisms are poorly understood. This study was undertaken to investigate the role of oxidative stress in catecholamine-induced heart dysfunction. Treatment of rats for 24 h with a high dose (40 mg/kg) of a synthetic catecholamine, isoproterenol, resulted in increased left ventricular end diastolic pressure, depressed rates of pressure development, and pressure decay as well as increased… CONTINUE READING
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