Role of oxidative stress in cadmium toxicity and carcinogenesis.

  title={Role of oxidative stress in cadmium toxicity and carcinogenesis.},
  author={Jie Liu and Wei Qu and Maria B. Kadiiska},
  journal={Toxicology and applied pharmacology},
  volume={238 3},
Cadmium (Cd) is a toxic metal, targeting the lung, liver, kidney, and testes following acute intoxication, and causing nephrotoxicity, immunotoxicity, osteotoxicity and tumors after prolonged exposures. Reactive oxygen species (ROS) are often implicated in Cd toxicology. This minireview focused on direct evidence for the generation of free radicals in intact animals following acute Cd overload and discussed the association of ROS in chronic Cd toxicity and carcinogenesis. Cd-generated… CONTINUE READING
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