Role of oxidative damage in toxicity of particulates.

  title={Role of oxidative damage in toxicity of particulates.},
  author={Peter M\oller and Nicklas Raun Jacobsen and Janne Kj{\ae}rsgaard Folkmann and Pernille H\ogh Danielsen and Lone Mikkelsen and Jette Gjerke Hemmingsen and Lise Kristine Vesterdal and Lykke Forchhammer and H{\aa}kan Wallin and Steffen Loft},
  journal={Free radical research},
  volume={44 1},
Particulates are small particles of solid or liquid suspended in liquid or air. In vitro studies show that particles generate reactive oxygen species, deplete endogenous antioxidants, alter mitochondrial function and produce oxidative damage to lipids and DNA. Surface area, reactivity and chemical composition play important roles in the oxidative potential of particulates. Studies in animal models indicate that particles from combustion processes (generated by combustion of wood or diesel oil… CONTINUE READING


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