Role of oxidative carbonylation in protein quality control and senescence.

@article{Nystrm2005RoleOO,
  title={Role of oxidative carbonylation in protein quality control and senescence.},
  author={Thomas Nystr{\"o}m},
  journal={The EMBO journal},
  year={2005},
  volume={24 7},
  pages={1311-7}
}
Proteins can become modified by a large number of reactions involving reactive oxygen species. Among these reactions, carbonylation has attracted a great deal of attention due to its irreversible and unrepairable nature. Carbonylated proteins are marked for proteolysis by the proteasome and the Lon protease but can escape degradation and form high-molecular-weight aggregates that accumulate with age. Such carbonylated aggregates can become cytotoxic and have been associated with a large number… CONTINUE READING
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