Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity.

@article{Chirino2009RoleOO,
  title={Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity.},
  author={Yolanda Irasema Chirino and Jos{\'e} Pedraza-Chaverri},
  journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie},
  year={2009},
  volume={61 3},
  pages={223-42}
}
cis-Diamminedichloroplatinum (II) (cisplatin) is an important chemotherapeutic agent useful in the treatment of several cancers; however, it has several side effects such as nephrotoxicity. The role of the oxidative and nitrosative stress in cisplatin-induced nephrotoxicity is additionally supported by the protective effect of several free radical scavengers and antioxidants. Furthermore, in in vitro experiments, antioxidants or reactive oxygen species (ROS) scavengers have a cytoprotective… CONTINUE READING
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