Role of oxidant stress in cytokine-induced activation of NF-κB in human aortic smooth muscle cells.

@article{Hoare1999RoleOO,
  title={Role of oxidant stress in cytokine-induced activation of NF-κB in human aortic smooth muscle cells.},
  author={Ginette S. Hoare and N{\'a}ndor Marczin and Adrian H Chester and Magdi Habib Yacoub},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={1999},
  volume={277 5},
  pages={H1975-H1984}
}
The transcription factor nuclear factor-κB (NF-κB) has been implicated in inflammatory and proliferative vascular mechanisms. Activated NF-κB has been documented in human atherosclerotic lesions, and its activation in human vascular smooth muscle cells (SMC) by cytokines has been reported. However, intracellular mechanisms mediating NF-κB activation in human SMC are poorly understood. The aim of this study was to explore the potential role of reactive oxygen species and oxidant stress as… CONTINUE READING