Role of ovarian hormones in the pathogenesis of impaired detrusor contractility: evidence in ovariectomized rodents.

@article{Zhu2001RoleOO,
  title={Role of ovarian hormones in the pathogenesis of impaired detrusor contractility: evidence in ovariectomized rodents.},
  author={Qiaozhi Zhu and Jennifer Leigh Ritchie and N Marouf and Stephane B. Dion and Neil M. Resnick and Ahmad Elbadawi and George A Kuchel},
  journal={The Journal of urology},
  year={2001},
  volume={166 3},
  pages={1136-41}
}
PURPOSE Although detrusor hyperactivity with impaired contractility is a common urodynamic finding in elderly subjects, to our knowledge its pathogenesis remains unknown. Biopsy studies indicate that subjects with detrusor hyperactivity and impaired contractility have ultrastructural evidence of dysjunction and degeneration patterns in isolated detrusor hyperactivity and impaired contractility, respectively. Based on the known cellular effects of estrogen we postulated that declines in ovarian… CONTINUE READING