Role of outer surface protein D in the Borrelia burgdorferi life cycle.

@article{Li2007RoleOO,
  title={Role of outer surface protein D in the Borrelia burgdorferi life cycle.},
  author={Xin Li and Girish Neelakanta and Xianzhong Liu and Deborah S. Beck and Fred S. Kantor and Durland Fish and John Flake Anderson and Erol Fikrig},
  journal={Infection and immunity},
  year={2007},
  volume={75 9},
  pages={4237-44}
}
Borrelia burgdorferi preferentially induces selected genes in mice or ticks, and studies suggest that ospD is down-regulated in response to host-specific signals. We now directly show that ospD expression is generally elevated within Ixodes scapularis compared with mice. We then assessed the importance of OspD throughout the spirochete life cycle by generating OspD-deficient B. burgdorferi and examining the mutant in the murine model of tick-transmitted Lyme borreliosis. The lack of OspD did… CONTINUE READING