Role of ouabain-like compound in the regulation of transmembrane sodium and potassium gradients in rats.

@article{Goto1997RoleOO,
  title={Role of ouabain-like compound in the regulation of transmembrane sodium and potassium gradients in rats.},
  author={Atsuo Goto and K. Yamada and Hiroshi Nagoshi and Yan Dan and Masao Omata},
  journal={Hypertension},
  year={1997},
  volume={30 3 Pt 2},
  pages={
          753-8
        }
}
A major biologically active Na,K-ATPase inhibitor in the mammalian body may be ouabain-like compound. We investigated the potential roles of circulating ouabain-like compound in the regulation of Na+ and K+ homeostasis in terms of Na+ and K+ distribution between the cells and the extracellular fluid (internal balance). First, we developed a population of rats immunized against ouabain to block the action of ouabain-like compound. We measured plasma and intracellular Na+ and K+ concentrations in… 
The change and significance of the Na+-K+-ATPase alpha-subunit in ouabain-hypertensive rats.
  • G. Tian, C. Dang, Z. Lu
  • Medicine
    Hypertension research : official journal of the Japanese Society of Hypertension
  • 2001
TLDR
The results suggest that the high level of ouabain and the change of the Na+-K+-ATPase alpha-subunit isoforms may play a critical role in hypertension.
Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.
TLDR
Rostafuroxin is indicated as the first example of a new class of antihypertensive agents designed to antagonize adducin and EO-hypertense mechanisms, and initial evidence of high tolerability and efficacy in hypertensive patients.
Neuronal function and alpha3 isoform of the Na/K-ATPase.
TLDR
The present status of several hypotheses on this account are reviewed, and their standing in application to recent data on the expression of isoforms of the Na/K-ATPase in the peripheral nervous system of vertebrate animals is reviewed.
Hypertension, Na+/Ca2+ exchanger, and Na+, K+-ATPase.
TLDR
Endogenous cardiac glycosides are secreted after high salt intake, and this inhibition results in the elevation of local Na+ on the submembrane area, resulting in vasoconstriction, which may have enabled how to link dietary salt to hypertension.
Role of endogenous brain "ouabain" in the sympathoexcitatory and pressor effects of sodium.
TLDR
The discovery of the importance of brain "ouabain" in cardiovascular regulation creates a novel path for the development of antihypertensive pharmacopeia.
Chronic hypertension induced by ouabain but not digoxin in the rat: antihypertensive effect of digoxin and digitoxin.
TLDR
It is suggested that sodium pump inhibition is not the exclusive mediator of the hemodynamic effects of these cardiac glycosides and the presence of structure-specific mechanisms that regulate their tissue levels and effects on long-term blood pressure is demonstrated.
Chronic Hypertension Digoxin in the Rat : Digoxin Induced by Ouabain but Not Antihypertensive Effect of and Digitoxin
Elevated circulating levels of an endogenous ouabain (EO) have been associated with essential hypertension. To investigate structure-activity relationships relevant to blood pressure, we infused
Ouabain‐like factor
  • A. Goto, Kaoru Yamada
  • Chemistry, Medicine
    Current opinion in nephrology and hypertension
  • 1998
TLDR
Several important questions remain, however, before it can be concluded that ouabain-like factor is indeed involved in the regulation of sodium homeostasis and blood pressure.
PST 2238: A New Antihypertensive Compound that Modulates Na+,K+‐ATPase and Antagonizes the Pressor Effect of OLF
TLDR
The future success of a new therapy for hypertension will depend upon the able to understand the molecular and genetic mechanisms operating in a subset of patients and the ability to develop new drugs able to correct such mechanisms.
Endogenous digitalislike factor: an update.
  • H. Takahashi
  • Medicine
    Hypertension research : official journal of the Japanese Society of Hypertension
  • 2000
This issue of Hypertension Research contains the review and original articles presented at the International Symposium on Natriuretic and Digitalis-Like Factors held in Chitose, Hokkaido, Japan, on
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