Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes.

Abstract

During the past several years, important advances have been made in our understanding of the mechanisms that regulate the expression of genes that determine drug clearance, including phase I and phase II drug-metabolising enzymes and drug transporters. Orphan nuclear receptors have been recognised as key mediators of drug-induced changes in both metabolism… (More)

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@article{Wang2003RoleOO, title={Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes.}, author={Hongbing Wang and Edward L. Lecluyse}, journal={Clinical pharmacokinetics}, year={2003}, volume={42 15}, pages={1331-57} }