Role of organic cation transporters in drug-drug interaction.

  title={Role of organic cation transporters in drug-drug interaction.},
  author={Hermann Koepsell},
  journal={Expert opinion on drug metabolism & toxicology},
  volume={11 10},
INTRODUCTION Organic cation transporters OCT1, OCT2 and OCT3 expressed in the small intestine, liver, brain and other organs play important roles in absorption, excretion and distribution of cationic drugs. Drug-drug interactions at OCTs may change pharmacokinetics, pharmacodynamics and drug toxicity. Knowledge about physiological and biomedical functions of OCTs and the molecular mechanisms of transport and inhibition is required to anticipate drug-drug interactions and their potential… CONTINUE READING


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