Role of organic cation transporters in drug-drug interaction.

@article{Koepsell2015RoleOO,
  title={Role of organic cation transporters in drug-drug interaction.},
  author={Hermann Koepsell},
  journal={Expert opinion on drug metabolism & toxicology},
  year={2015},
  volume={11 10},
  pages={1619-33}
}
INTRODUCTION Organic cation transporters OCT1, OCT2 and OCT3 expressed in the small intestine, liver, brain and other organs play important roles in absorption, excretion and distribution of cationic drugs. Drug-drug interactions at OCTs may change pharmacokinetics, pharmacodynamics and drug toxicity. Knowledge about physiological and biomedical functions of OCTs and the molecular mechanisms of transport and inhibition is required to anticipate drug-drug interactions and their potential… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

β2-adrenergic receptor-mediated in vitro regulation of human hepatic drug transporter expression by epinephrine.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences • 2017
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 99 references

Polymorphic transporters and platinum pharmacodynamics.

Drug metabolism and pharmacokinetics • 2013
View 5 Excerpts
Highly Influenced

Common drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake.

Drug metabolism and disposition: the biological fate of chemicals • 2014
View 7 Excerpts
Highly Influenced

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.

Proceedings of the National Academy of Sciences of the United States of America • 2014
View 8 Excerpts
Highly Influenced

Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine.

American journal of physiology. Gastrointestinal and liver physiology • 2004
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…