Role of organic anion-transporting polypeptides for cellular mesalazine (5-aminosalicylic acid) uptake.

@article{Koenig2011RoleOO,
  title={Role of organic anion-transporting polypeptides for cellular mesalazine (5-aminosalicylic acid) uptake.},
  author={Joerg Koenig and Hartmut Glaeser and Markus Keiser and Kathrin Mandery and Ulrich Klotz and Martin F. Fromm},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2011},
  volume={39 6},
  pages={1097-102}
}
The therapeutic effects and metabolism of mesalazine (5-aminosalicylic acid) in patients with inflammatory bowel disease require intracellular accumulation of the drug in intestinal epithelial cells and hepatocytes. The molecular mechanisms of mesalazine uptake into cells have not been characterized so far. Using human embryonic kidney cells stably expressing uptake transporters of the organic anion-transporting polypeptide (OATP) family, which are expressed in human intestine and/or liver, we… CONTINUE READING