Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity.

@article{Enomoto2002RoleOO,
  title={Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity.},
  author={Atsushi Enomoto and Michio Takeda and Akihiro Tojo and Takashi Sekine and Seok Ho Cha and Suparat Khamdang and Fumio Takayama and Isao Aoyama and Sakurako Nakamura and Hitoshi Endou and Toshimitsu Niwa},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2002},
  volume={13 7},
  pages={1711-20}
}
In uremic patients, various uremic toxins are accumulated and exert various biologic effects on uremia. Indoxyl sulfate (IS) is one of uremic toxins that is derived from dietary protein, and serum levels of IS are markedly increased in both uremic rats and patients. It has been previously reported that the accumulation of IS promotes the progression of chronic renal failure (CRF). This study demonstrates the role of rat organic anion transporters (rOATs) in the transport of IS and the induction… CONTINUE READING