Role of orexin in the central regulation of glucose and energy homeostasis.

@article{Tsuneki2012RoleOO,
  title={Role of orexin in the central regulation of glucose and energy homeostasis.},
  author={Hiroshi Tsuneki and Tsutomu Wada and Toshiyasu Sasaoka},
  journal={Endocrine journal},
  year={2012},
  volume={59 5},
  pages={365-74}
}
Hypothalamic orexin neurons are known to regulate sleep/wake stability, feeding behavior, emotions, autonomic nerve activity, and whole-body energy metabolism. In addition, emerging evidence indicates that orexin contributes to central regulation of glucose homeostasis. Intriguingly, central administration of orexin is reported to cause blood glucose-elevating effect or blood glucose-lowering effect in rodents, depending on the experimental conditions. Here we reviewed the recent reports… CONTINUE READING
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