Role of orexin/hypocretin in dependence and addiction.

  title={Role of orexin/hypocretin in dependence and addiction.},
  author={Ruth Sharf and Maysa Sarhan and Ralph Joseph Dileone},
  journal={Brain research},
The orexins (or hypocretins) are hypothalamic neuropeptides that have been implicated in a variety of behaviors ranging from feeding to sleep and arousal. Evidence from animal models suggests a role for orexins in reward processing and drug addiction. In this review, we discuss orexin's interaction with the mesocorticolimbic reward pathway and the effects of drugs of abuse on the orexin system. We further review models of drug dependence and addiction and describe behavioral alterations that… CONTINUE READING

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