Role of olfaction in the conditioned sucrose preference of sweet-ageusic T1R3 knockout mice.

@article{Zukerman2009RoleOO,
  title={Role of olfaction in the conditioned sucrose preference of sweet-ageusic T1R3 knockout mice.},
  author={Steven Zukerman and Khalid Touzani and Robert F Margolskee and Anthony Sclafani},
  journal={Chemical senses},
  year={2009},
  volume={34 8},
  pages={
          685-94
        }
}
Prior work has shown that sweet taste-deficient T1R3 knockout (KO) mice developed significant sucrose preferences when given long-term sugar versus water tests. The current study investigated the role of olfaction in this experience-conditioned sucrose preference. T1R3 KO and C57BL/6 wild-type (WT) mice were given 24-h sugar versus water tests with ascending concentrations of sucrose (0.5-32%), after which the mice received olfactory bulbectomy (OBx) or sham surgery. When retested with sucrose… CONTINUE READING

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