Role of ocular pigment epithelial cells in immune privilege

  title={Role of ocular pigment epithelial cells in immune privilege},
  author={Ph.D. Sunao Sugita},
  journal={Archivum Immunologiae et Therapiae Experimentalis},
The ocular microenvironment is both immunosuppressive and anti-inflammatory in nature. Pigment epithelial (PE) cells isolated from the eye possess the ability to suppress the T cell receptor-dependent activation of T cells and the induction of regulatory T cells in vitro. This property is dependent on the cells’ capacity to produce cell-surface and soluble inhibitory molecules, for example CD86 (B7-2), transforming growth factor (TGF)-β, thrombospondin-1, programmed cell death 1 ligand 1 (PD-L1… CONTINUE READING

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