Role of nucleus accumbens shell neuronal ensembles in context-induced reinstatement of cocaine-seeking.

@article{Cruz2014RoleON,
  title={Role of nucleus accumbens shell neuronal ensembles in context-induced reinstatement of cocaine-seeking.},
  author={F{\'a}bio Cardoso Cruz and Klil R Babin and Rodrigo Molini Le{\~a}o and Evan M Goldart and Jennifer M Bossert and Yavin Shaham and Bruce T Hope},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 22},
  pages={7437-46}
}
Environmental contexts previously associated with drug use provoke relapse to drug use in humans and reinstatement of drug seeking in animal models of drug relapse. We examined whether context-induced reinstatement of cocaine seeking is mediated by activation of context-selected nucleus accumbens neurons. We trained rats to self-administer cocaine in Context A and extinguished their lever-pressing in a distinct Context B. On test day, reexposure to the cocaine-associated Context A reinstated… CONTINUE READING

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