Role of nuclear factor-kappa B in melanoma.

  title={Role of nuclear factor-kappa B in melanoma.},
  author={Katayoun Izadshenas Amiri and Ann Richmond},
  journal={Cancer metastasis reviews},
  volume={24 2},
Nuclear Factor-kappa B (NF-kappa B) is an inducible transcription factor that regulates the expression of many genes involved in the immune response. Recently, NF-kappa B activity has been shown to be upregulated in many cancers, including melanoma. Data indicate that the enhanced activation of NF-kappa B may be due to deregulations in upstream signaling pathways such as Ras/Raf, PI3K/Akt, and NIK. Multiple studies have shown that NF-kappa B is involved in the regulation of apoptosis… CONTINUE READING

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